Exosome Delivery Technology

Exosome Delivery Technology

Nanoparticles, particularly exosomes, are naturally produced in great quantities by human stem cells, including the adult stem cells used by BioRegenerative Sciences, Inc. if care is taken to correctly process the stem cells in the laboratory. While many other, competing technologies don’t produce exosomes, at BRS we use care in our Smart Molecules Expression SystemTM to produce the full complement of molecules and exosomes.

Exosomes are a nanosphere produced by stem cells for the purposes of protecting, and packaging hundreds of types of signaling molecules into one delivery vehicle so that the whole collection of molecules can be co-delivered in time and space and therefore utilized as one synergistically acting set of molecules by the neighboring target cell. Therefore, the exosome is an important device for the delivery of “Systems Therapeutics.” Exosomes are smart nanospheres given their ability to easily diffuse through tissues, seek out target cells, pass the brain-blood barrier, and exhibit immunoprivilege. The lipid bilayer of the exosome contains transmembrane proteins with a variety of external peptide sequences, and numerous polysaccharides and proteins on the outer leaflet that also help to impart smart behavior to the liposome-like structure.

Further, synthetic biology techniques and state-dependent regulation of the manufacture of the exosome by the stem cell can lead to important manipulation of many characteristics of the nanosphere for pharmaceutical delivery purposes. Defined manipulation of these naturally produced nanospheres can be useful for modifying the content, and the targeting and delivery characteristics of the nanosphere. Therefore, the exosome represents a powerful new platform technology to develop and scale-up a very safe and efficacious drug delivery system useful for many different drug dosing regimens of the S2RM molecules, and for delivery to most parts of the body.