Therapeutics

The degree to, and the mechanisms through, which stem cells are able to build, maintain, and heal the body resides mostly in the release of a multitude of molecules, called stem cell released molecules (SRM). A fundamentally new type of therapeutic, called a “systems therapeutic,” can be realized by reverse engineering the mechanisms of the SRM processes in the human body. About four days following the fertilization of a human egg, the stem cells in the blastocyst begin to differentiate and become pluripotent instead of totipotent, thus being able to differentiate into a more types of adult cell.

Recent data demonstrates that the composition of the SRM is different for each type of adult stem cell, as well as for different states of each cell type. Although systems biology has been successfully used to analyze multiple pathways, the approach is often used to develop a small molecule interacting at only one pathway in the system. A new model is emerging in biology where systems biology is used to develop a new technology acting at multiple pathways called “systems therapeutics.”

TherapeuticsA natural set of healing pathways in the human that uses SRM is instructive and of practical use in developing systems therapeutics. Endogenous SRM processes in the human body use a combination of SRM from two or more stem cell types, designated as S2RM, doing so under various state dependent conditions for each cell type. The approach at BioRegenerative Sciences, Inc. is to use state-dependent SRM from two or more stem cell types, S2RM technology, to develop a new class of therapeutics called “systems therapeutics.” Given the ubiquitous and powerful nature of innate S2RM-based healing in the human body, this “systems therapeutic” approach using S2RM technology will be important for the development of anti-cancer therapeutics, antimicrobials, antivirals, injectibles for glaucoma and macular degeneration, wound care products and procedures, and a number of other therapeutics for many indications.